What is Climbazole?
Climbazole is an imidazole-based antifungal agent commonly used in cosmetics and personal care products. It is classified as a monochlorobenzene, aromatic ether, ketone and hemiaminal ether. It helps control the growth of fungi and yeasts, particularly Malassezia species, which are the main cause of dandruff, seborrheic dermatitis (scaly and red patches on the scalp), eczema and other scalp irritations.
Climbazole is a common ingredient in anti-dandruff shampoos, scalp treatments and other hair-care products to help control fungal growth. It is also useful as a topical antifungal and antimicrobial agent for treating fungal skin infections.
Macsen Labs is an Indian GMP, DMF & ISO-certified manufacturer and supplier of high-quality Climbazole (CAS 38083-17-9), with expertise in specialty chemical manufacturing and cosmetic ingredients.
| PRODUCT SPECIFICATIONS | |
|---|---|
| Name of Product | Climbazole |
| IUPAC Name | 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one |
| Synonyms | Climbazole; Baypival; Climbazol; Crinipan AD; Climbazolum |
| CAS No | 38083-17-9 |
| Molecular Formula | C15H17ClN2O2 |
| Molecular Weight | 292.76 g/mol |
| PubChem CID | 37907 |
| GMP | ✓ |
| DMF | ✓ |
Chemical Properties of Climbazole
| SR. No | Criteria | Limit/Specification |
|---|---|---|
| 1 | Appearance (Form) | Solid Powder |
| 2 | Appearance (Color) | White to Off-white |
| 3 | Solubility | Soluble in DMSO & Ethanol Insoluble in Water |
| 4 | Identification by IR | The infrared spectrum of the test sample should match that of Climbazole RS |
| 5 | Assay | ≥ 99% |
| 6 | Melting Point | Between 94.0 to 98.0 °C |
| 7 | P-Chlorophenol | Maximum 0.015% |
| 8 | Loss on Drying (50°C, under vacuum) | NMT 0.5 % |
| 9 | Sulfated Ash | NMT 0.20 % |
Uses of Climbazole
- Climbazole is a common active constituent found in anti-dandruff shampoos. It controls and reduces dandruff by inhibiting the growth of Malassezia spp. fungi, which are known to contribute to the formation of dandruff.
- It can be found in lotions, creams, and serums designed to treat scalp conditions such as seborrheic dermatitis, scalp psoriasis, and fungal infections.
- It can also be used as an active ingredient in topical creams or ointments for the treatment of various fungal infections of the skin, such as athlete’s foot, jock itch, and ringworm.
Side effects of Climbazole
The side effects which may be caused due to the use of Climbazole are as follows-
- Skin irritation, including redness, itching, or a burning sensation at the application site.
- Increased sensitivity to sunlight (photosensitivity) in some individuals.
- May cause temporary dryness or changes in the texture of the hair.
FAQs
Q. Is Ketoconazole and Climbazole same?
Ketoconazole and Climbazole are both broad-spectrum antifungal agents used in topical products like shampoos and conditioners for the management of dandruff, seborrheic dermatitis, and scalp fungal infections. However, they both have different chemical structures and properties. Also, ketoconazole is only available as a prescription medication whereas Climbazole is often found in over-the-counter personal care products.
Q. What is Climbazole used for?
Climbazole is an antifungal ingredient that is mainly used in anti-dandruff shampoos, scalp treatments, and hair-care products. It is effective in regulating Malassezia yeast that causes dandruff and seborrheic dermatitis.Â
Q. Is Climbazole safe for hair and scalp?
Climbazole is considered safe when used within permitted concentrations in cosmetic formulations. However, some individuals may experience mild scalp irritation or allergic reactions.
Q.Can Climbazole be used daily?
Depending on the formulation and instructions for use, climbazole-containing shampoos can be used regularly. The frequency depends on scalp condition, hair type and the concentration of the active ingredients.
Buy high-quality Climbazole for anti-dandruff shampoos, scalp treatments, and topical formulations from GMP, DMF & ISO-certified supplier Macsen Laboratories. For buying, send us an enquiry now-