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What is Atovaquone
Atovaquone is a synthetic naphthoquinone compound with antiprotozoal activity. It is a yellow crystalline solid that is practically insoluble in water. It is sold under the brand name Mepron (oral suspension) and is generally used for the treatment and prevention of Pneumocystis jirovecii pneumonia (PCP).
Macsen Laboratories is the supplier of high-quality Atovaquone with ISO certification.
| PRODUCT SPECIFICATIONS | |
|---|---|
| Name of Product | Atovaquone |
| IUPAC Name | 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione |
| Synonyms | Mepron; Wellvone; Acuvel; cis-Atovaquone; Atovaquona; atovacuona; |
| CAS No | 95233-18-4 |
| Molecular Formula | C22H19ClO3 |
| Molar Mass | 366.8 g/mol |
| Pubchem CID | 74989 |
| Pubchem SID | 469688495 |
Chemical Properties
| SR. No | Criteria | Limit/Specification |
|---|---|---|
| 1 | Appearance (Form) | Solid Powder |
| 2 | Appearance (Colour) | Yellow |
| 3 | Melting point | 216-219 °C |
| 4 | Storage temp. | 2 to 8 °C, dark |
Mechanism of action
Atovaquone is a competitive inhibitor of ubiquinol and blocks the mitochondrial electron transport at complex III ( bc1 complex) of the respiratory chain of protozoa, thereby inhibiting pyrimidine synthesis, preventing DNA synthesis and leading to protozoal death.
Uses
Atovaquone is used to prevent and treat:
- Pneumocystis jiroveci pneumonia (PCP) in adults and children 13 years of age and older who cannot tolerate other medicines, such as trimethoprim-sulfamethoxazole (TMP-SMX).
- Babesia, in conjunction with azithromycin.
- Toxoplasmosis.
- Malaria (Atovaquone is used as a combination preparation with proguanil).
Side effects
Common side effects include:
- Nausea & Vomiting
- Diarrhoea
- Dizziness/Headache
- Anxiety
- Difficulty falling asleep or staying asleep
- Runny nose
Serious side effects include:
- Rash
- Fever
- Swelling of the eyes, face, lips, tongue, mouth, or throat
- Hives
- Difficulty breathing or swallowing
- Hoarseness or throat tightness
FAQs
Q. What is atovaquone-proguanil used for?
Atovaquone and proguanil is a combination medicine used to treat or prevent malaria. It is effective against drug-sensitive and drug-resistant P. falciparum. It is also used to prevent malaria infection in travellers who visit areas where malaria is common.
Q. Is atovaquone an antibiotic?
Atovaquone is an antibiotic. It is an antiprotozoal agent.
Q. Does atovaquone treat Covid?
Atovaquone has been shown in a preliminary study to prevent SARS-CoV-2 replication in vitro. Atovaquone is now undergoing clinical studies in the United States (since December 2021) for the treatment of COVID-19.
Q. How long does atovaquone stay in your system?
The elimination half-life of atovaquone is about 2 to 3 days in adult patients.
Buy the best quality Atovaquone through Macsen Laboratories.