What is Isosulfan Blue?
Isosulfan Blue is a visual lymphatic imaging agent that is injected into the tumor site’s periphery, where it binds to the lymphatic system and assists in the surgical detection of tumor sentinel nodes by staining them blue.
The product is currently under development. Samples are available from R&D.
| PRODUCT SPECIFICATIONS | |
|---|---|
| Name of Product | Isosulfan Blue |
| IUPAC Name | sodium;2-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,4-disulfonate |
| Synonyms | Lymphazurin; Sulphan Blue; Sulfanblau; Disulphin Blau; Azul de Isosulfan; Bleu isosulfan; PATENTBLUEVIOLET |
| CAS No | 68238-36-8 |
| Molecular Formula | C27H33N2O6S2 |
| Molecular Weight | 566.7 g/mol |
| Pubchem CID | 50108 |
| Pubchem SID | 462770291 |
TECHNICAL SPECIFICATIONS
| SR. No | Criteria | Limit/Specification |
|---|---|---|
| 1 | Appearance | greenish-blue colour |
| 2 | Heat Resistance °C | 160°C |
| 3 | Density, g/cm3 | 1.15 |
| 4 | Residue on 80mesh | 5.0 %max |
| 5 | Water Soluble | 1.0 % max |
| 6 | Volatile Matter at 105°C | 1.0 %max |
| 7 | Tinting Strength | 95-105 % |
Uses
- It is utilized as a contrast agent to identify lymphatic vessels in teenage varicoceles with high retroperitoneal ligation and to detect lymphatic vessel leakage after surgery.
- It is used in conjunction with lymphography to see the lymphatic system draining the injection site (in primary and secondary lymphedema of the limbs; chyluria, chylous ascites or chylothorax; lymph node involvement by the main or secondary tumor).
Side effects
Some of the side effects associated with the use of Isosulfan Blue are as follows-
- Difficulty with swallowing
- Dizziness
- Fast heartbeat (Tachycardia)
- Fast, weak pulse
- Hives or welts
- Shortness of breath
- Tightness in the chest
- Unusual tiredness or weakness
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